Chemical synthesis of Ser/Thr AMPylated peptides

被引：8

作者：

Al-Eryani, Rwaida A. ^{[1
]}

Li, Yan ^{[1
]}

Ball, Haydn L. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Prot Chem Technol Ctr, Dallas, TX 75390 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 13期

关键词：

AMPylation; 2; 3 '-Isopropylidene adenosine; H-Phosphonate; Bis(diethylamino) chlorophosphine; Benzotriazole-1-yl oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBOP); AMP; SPPS; SOLID-PHASE; PHOSPHONATE;

D O I：

10.1016/j.tetlet.2010.01.097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the solid phase chemical synthesis of AMPylated Ser/Thr containing peptides is described. Peptides were phosphonylated using the H-phosphonate method, then the adenosine moiety was introduced using 2',3'-isopropylidene adenosine and the condensing reagent PyBOP. Oxidation with iodine yielded the desired AMPylated product in good yield following acidolytic cleavage from the resin support. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1730 / 1731

页数：2

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