Identification of genes predominantly expressed in human macrophages

被引：21

作者：

Svensson, PA

Hägg, DA

Jenås, M

Englund, MCO

Hulten, LM

Ohlsson, BG

Hulthe, J

Wiklund, O

Carlsson, B

Fagerberg, B

Carlsson, LMS

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Res Ctr Endocrinol & Metabol, Dept Internal Med, S-41345 Gothenburg, Sweden

[2] Gothenburg Univ, Wallenberg Lab Cardiovasc Res, Sahlgrenska Acad, S-41345 Gothenburg, Sweden

来源：

ATHEROSCLEROSIS | 2004年 / 177卷 / 02期

关键词：

macrophages; human; atherosclerosis; DNA microarray; IL1RN;

D O I：

10.1016/j.atherosclerosis.2004.07.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Identification of cell and tissue specific genes may provide novel insights to signaling systems and functions. Macrophages play a key role in many diseases including atherosclerosis. Using DNA microarrays we compared the expression of approximately 10,000 genes in 56 human tissues and identified 23 genes with predominant expression in macrophages. The identified genes include both genes known to be macrophage specific and genes previously not well described in this cell type. Tissue distribution of two genes, liver X receptor (LXR) alpha and interleukin-1 receptor antagonist (IL1RN), was verified by real-time RT-PCR. We conclude that comparison of expression profiles from a large number of tissues can be used to identify genes that are predominantly expressed in certain tissues. Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：287 / 290

页数：4

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