Accessory factor-bZIP-DNA interactions

被引：20

作者：

Baranger, AM ^{[1
]}

机构：

[1] Wesleyan Univ, Dept Chem, Middletown, CT 06459 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 01期

关键词：

D O I：

10.1016/S1367-5931(98)80031-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA binding and transcriptional activation by basic region leucine zipper (bZIP) proteins can be enhanced by accessory factors. In the past year, three accessory factor-bZIP-DNA complexes have been investigated extensively. Experiments have probed the effect of accessory factors on bZIP-DNA specificity, the residues that participate in stabilizing these complexes, the contribution of DNA conformation to accessory factor-bZlP interactions, and the relative stabilization of bZIP dimerization and DNA binding by accessary factors.

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页码：18 / 23

页数：6

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