Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

被引：65

作者：

Kirkpatrick, WR

McAtee, RK

Fothergill, AW

Rinaldi, MG

Patterson, TF

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Med, Div Infect Dis, San Antonio, TX 78229 USA

[2] Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78229 USA

[3] S Texas Vet Hlth Care Syst, Audie Murphy Div, San Antonio, TX 78284 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 10期

关键词：

D O I：

10.1128/AAC.44.10.2865-2868.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericin B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

引用

收藏

页码：2865 / 2868

页数：4

相关论文

共 21 条

[1] In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B [J].

Abraham, OC ;

Manavathu, EK ;

Cutright, JL ;

Chandrasekar, PH .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1999, 33 (01) :7-11

[2] In vitro studies of two triazole antifungal agents (Voriconazole [UK-109,496] and fluconazole) against Candida species [J].

Barry, AL ;

Brown, SD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (08) :1948-1949

[3]

Clancy CJ, 1998, EUR J CLIN MICROBIOL, V17, P573

[4] Comparison of the in-vitro activity of voriconazole (UK-109,496), itraconazole and amphotericin B against clinical isolates of Aspergillus fumigatus [J].

Cuenca-Estrella, M ;

Rodríguez-Tudela, JL ;

Mellado, E ;

Martínez-Suárez, JV ;

Monzón, A .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (04) :531-533

[5] Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection [J].

Denning, DW ;

Radford, SA ;

Oakley, KL ;

Hall, L ;

Johnson, EM ;

Warnock, DW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (03) :401-414

[6] Invasive aspergillosis [J].

Denning, DW .

CLINICAL INFECTIOUS DISEASES, 1998, 26 (04) :781-803

[7] Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts [J].

Espinel-Ingroff, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (10) :2950-2956

[8]

GRAYBILL JR, 1984, AM REV RESPIR DIS, V129, P292

[9] Aspergillus fumigatus and aspergillosis [J].

Latgé, JP .

CLINICAL MICROBIOLOGY REVIEWS, 1999, 12 (02) :310-+

[10] Optimizing voriconazole susceptibility testing of Candida:: Effects of incubation time, endpoint rule, species of Candida, and level of fluconazole susceptibility [J].

Lozano-Chiu, M ;

Arikan, S ;

Paetznick, VL ;

Anaissie, EJ ;

Rex, JH .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (09) :2755-2759