Synthesis of methoxy and hydroxy containing tetralones: versatile intermediates for the preparation of biologically relevant molecules

被引：18

作者：

Ghatak, A

Dorsey, JM

Garner, CM

Pinney, KG

机构：

[1] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA

[2] Baylor Univ, Ctr Drug Discovery, Waco, TX 76798 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(03)00715-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 5-hydroxy-6-methoxy-1-tetralone and the 7-hydroxy regioisomer along with the corresponding 5,7-dihydroxy analog has been achieved using an efficient directed metallation procedure followed by a regioselective methylene oxidation. This methodology represents a general synthetic route for the preparation of highly oxygenated tetralone analogs which are versatile building blocks for the construction of molecules of biological interest. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：4145 / 4148

页数：4

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