Synthesis and in vitro antibacterial activities of novel conformationally restricted hygromycin A analogues

被引：10

作者：

Cooper, CB

Blair, KT

Jones, CS

Minich, ML

机构：

[1] Pfizer Inc., Central Research Division, Groton

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(97)00307-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of semisynthetic conformationally restricted hygromycin A analogues are described. Antibacterial results from these compounds suggest active conformations for this class of agents. (C) 1997 Elsevier Science Ltd.

引用

页码：1747 / 1752

页数：6

共 14 条

[1] TOTAL SYNTHESIS OF ANTIBIOTIC HYGROMYCIN-A [J].

CHIDA, N ;

OHTSUKA, M ;

NAKAZAWA, K ;

OGAWA, S .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (09) :2976-2983

[2]

GUERRERO MDC, 1980, EUR J BIOCHEM, V107, P490

[3] SEMISYNTHETIC MODIFICATION OF HYGROMYCIN-A .2. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF ARYL ANALOGS [J].

HECKER, SJ ;

COOPER, CB ;

BLAIR, KT ;

LILLEY, SC ;

MINICH, ML ;

WERNER, KM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (02) :289-294

[4] SEMISYNTHETIC MODIFICATION OF HYGROMYCIN-A .3. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF AMINOCYCLITOL ANALOGS [J].

HECKER, SJ ;

LILLEY, SC ;

MINICH, ML ;

WERNER, KM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (09) :1015-1018

[5] HYGROMYCIN-A - PREPARATION OF AMINOCYCLITOL ANALOGS DEFINING THE MINIMUM FUNCTIONALITY REQUIRED FOR BIOLOGICAL-ACTIVITY [J].

HECKER, SJ ;

LILLEY, SC ;

WERNER, KM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (09) :1043-1046

[6] SEMISYNTHETIC MODIFICATION OF HYGROMYCIN-A .1. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF VINYL METHYL AND AMIDE ANALOGS [J].

HECKER, SJ ;

MINICH, ML ;

WERNER, KM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (06) :533-536

[7] SEMISYNTHETIC HYGROMYCIN-A ANALOGS - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF DERIVATIVES LACKING THE FURANOSE MOIETY [J].

JAYNES, BH ;

ELLIOTT, NC ;

SCHICHO, DL .

JOURNAL OF ANTIBIOTICS, 1992, 45 (10) :1705-1707

[8] SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY OF HYGROMYCIN-A ANALOGS MODIFIED AT THE C4' ARYL POSITION [J].

JAYNES, BH ;

COOPER, CB ;

HECKER, SJ ;

BLAIR, KT ;

ELLIOTT, NC ;

LILLEY, SC ;

MINICH, ML ;

SCHICHO, DL ;

WERNER, KM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (08) :1531-1536

[9]

MANN RL, 1953, ANTIBIOT CHEMOTHER, V3, P1279

[10] FORMATION OF FUNCTIONALIZED DIHYDROBENZOFURANS BY RADICAL CYCLIZATION [J].

MEIJS, GF ;

BECKWITH, ALJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (19) :5890-5893

← 1 2 →