HYGROMYCIN-A - PREPARATION OF AMINOCYCLITOL ANALOGS DEFINING THE MINIMUM FUNCTIONALITY REQUIRED FOR BIOLOGICAL-ACTIVITY

被引：15

作者：

HECKER, SJ

LILLEY, SC

WERNER, KM

机构：

[1] Pfizer Inc, Central Research Division, Groton

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80615-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogs of hygromycin A in which the aminocyclitol is replaced by dihydroxycyclohexylamine and trihydroxycyclohexylamine (with stereochemistry matching that of the natural product) have been prepared. The latter was prepared both in racemic form (starting with 1,3-cyclohexadiene) and as a single enantiomer (by degradation of hygromycin A.) Antibacterial activities against key animal health pathogens are reported.

引用

页码：1043 / 1046

页数：4

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