SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY OF HYGROMYCIN-A ANALOGS MODIFIED AT THE C4' ARYL POSITION

被引：9

作者：

JAYNES, BH

COOPER, CB

HECKER, SJ

BLAIR, KT

ELLIOTT, NC

LILLEY, SC

MINICH, ML

SCHICHO, DL

WERNER, KM

机构：

[1] Pfizer Inc, Central Research Division, Groton

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80012-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A variety of hygromycin A analogs are described which contain modifications of or replacements for the natural sugar. Antibacterial activities against Serpulina (Treponema) hyodysenteriae, an important animal health pathogen, are reported and indicate that small lipophilic C4' substituents serve as useful sugar surrogates in the hygromycin A class.

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收藏

页码：1531 / 1536

页数：6

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