Genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background

被引:19
作者
Davis, Richard C. [1 ]
Jin, Angela
Rosales, Melenie
Yu, Suzanne
Xia, Xiaoyu
Ranola, Kathleen
Schadt, Eric E.
Lusis, Aldons J.
机构
[1] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA
[4] Rosetta Inpharmat Merck Inc, Seattle, WA 98109 USA
关键词
mouse; congenic; genetics;
D O I
10.1016/j.ygeno.2007.05.009
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We previously reported the construction of two sets of heterozygous congenic strains spanning the mouse genome. For both sets, C57BL/6J was employed as the background strain while DNA from either DBA/2 or CAST/Ei was introgressed to form the congenic region. We have subsequently bred most of these strains to produce homozygous breeding stocks. Here, we report the characterization of the strain set based on CAST/Ei. CAST/Ei is the most genetically distant strain within the Mus mus species and many trait variations relevant to common diseases have been identified in CAST/Ei mice. Despite breeding difficulties for some congenic regions, presumably due to incompatible allelic variations between CAST/Ei and C57BL/6, the resulting congenic strains cover about 80% of the autosomal chromosomes and will be useful as a resource for the further analysis of quantitative trait loci between the strains. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:306 / 313
页数:8
相关论文
共 35 条
[1]   Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus [J].
Clee, Susanne M. ;
Yandell, Brian S. ;
Schueler, Kathryn M. ;
Rabaglia, Mary E. ;
Richards, Oliver C. ;
Raines, Summer M. ;
Kabara, Edward A. ;
Klass, Daniel M. ;
Mui, Eric T-K ;
Stapleton, Donald S. ;
Gray-Keller, Mark P. ;
Young, Matthew B. ;
Stoehr, Jonathan P. ;
Lan, Hong ;
Boronenkov, Igor ;
Raess, Philipp W. ;
Flowers, Matthew T. ;
Attie, Alan D. .
NATURE GENETICS, 2006, 38 (06) :688-693
[2]   Quantitative trait loci affecting growth in high growth (hg) mice [J].
Corva, PM ;
Horvat, S ;
Medrano, JF .
MAMMALIAN GENOME, 2001, 12 (04) :284-290
[3]   A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background [J].
Davis, RC ;
Schadt, EE ;
Smith, DJ ;
Hsieh, EWY ;
Cervino, ACL ;
van Nas, A ;
Rosales, M ;
Doss, S ;
Meng, H ;
Allayee, H ;
Lusis, AJ .
GENOMICS, 2005, 86 (03) :259-270
[4]   Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background [J].
Edderkaoui, B ;
Baylink, DJ ;
Beamer, WG ;
Wergedal, JE ;
Dunn, NR ;
Shultz, KL ;
Mohan, S .
JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (01) :97-104
[5]   Dissection of multigenic obesity traits in congenic mouse strains [J].
Estrada-Smith, D ;
Castellani, LW ;
Wong, H ;
Wen, PZ ;
Chui, A ;
Lusis, AJ ;
Davis, RC .
MAMMALIAN GENOME, 2004, 15 (01) :14-22
[6]   Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice [J].
Estrada-Smith, Daria ;
Collins, Alan R. ;
Wang, Xuping ;
Crockett, Craig ;
Castellani, Lawrence ;
Lusis, Aldons J. ;
Davis, Richard C. .
DIABETES, 2006, 55 (08) :2265-2271
[7]   Strategies for mapping and cloning quantitative trait genes in rodents [J].
Flint, J ;
Valdar, W ;
Shifman, S ;
Mott, R .
NATURE REVIEWS GENETICS, 2005, 6 (04) :271-286
[8]   Gene expression between a congenic strain that contains a quantitative trait locus of high bone density from CAST/EiJ and its wild-type strain C57BL/6J [J].
Gu W. ;
Li X. ;
Lau W.K.-H. ;
Edderkaoui B. ;
Donahae L.R. ;
Rosen C.J. ;
Beamer W.G. ;
Shultz K.L. ;
Srivastava A. ;
Mohan S. ;
Baylink D.J. .
Functional & Integrative Genomics, 2002, 1 (6) :375-386
[9]   Construction of a BAC contig for a 3 cM biologically significant region of mouse chromosome 1 [J].
Gu, WK ;
Li, XM ;
Edderkaoui, B ;
Strong, DD ;
Lau, KHW ;
Beamer, WG ;
Donahae, LR ;
Mohan, S ;
Baylink, DJ .
GENETICA, 2002, 114 (01) :1-9
[10]   Highly multiplexed molecular inversion probe genotyping: Over 10,000 targeted SNPs genotyped in a single tube assay [J].
Hardenbol, P ;
Yu, FL ;
Belmont, J ;
MacKenzie, J ;
Bruckner, C ;
Brundage, T ;
Boudreau, A ;
Chow, S ;
Eberle, J ;
Erbilgin, A ;
Falkowski, M ;
Fitzgerald, R ;
Ghose, S ;
Iartchouk, O ;
Jain, M ;
Karlin-Neumann, G ;
Lu, XH ;
Miao, X ;
Moore, B ;
Moorhead, M ;
Namsaraev, E ;
Pasternak, S ;
Prakash, E ;
Tran, K ;
Wang, ZY ;
Jones, HB ;
Davis, RW ;
Willis, TD ;
Gibbs, RA .
GENOME RESEARCH, 2005, 15 (02) :269-275