Cyclic food restriction alters substrate utilization and abolishes protection from mammary carcinogenesis in female rats

被引:30
作者
Tagliaferro, AR
Ronan, AM
Meeker, LD
Thompson, HJ
Scott, AL
Sinha, D
机构
[1] UNIV NEW HAMPSHIRE, DEPT MATH, DURHAM, NH 03824 USA
[2] AMC CANC RES CTR, DIV LAB RES, DENVER, CO 80214 USA
关键词
food restriction; mammary carcinogenesis; energy metabolism; substrate utilization; rats;
D O I
10.1093/jn/126.5.1398
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
We tested the hypothesis that cyclic food restriction abolishes protection against mammary carcinogenesis. Virgin female Sprague Dawley rats (n = 159) were injected intraperitoneally with 25 mg/kg n-methyl-n-nitrosourea at 50 d of age. Eleven days later, rats were given free access to a 24.6 g fat/100 g AIN-76A diet (ad lib-c), fed in two meals (me-c), or fed in two meals restricted in weight by 33% for 1 wk followed by 3 wk of compensatory refeeding (me-r) for 18 wk or 4.5 restriction cycles. Energy and substrate utilization of 15 rats from each group was measured by indirect calorimetry. The me-r rats ate and weighed less (P < 0.0001), had a greater efficiency of food utilization (P < 0.01), and had a 12% higher incidence of mammary cancer (P < 0.0001) than ad lib-c rats after adjusting for the effect of final body weight. Resting metabolic rate was not different among groups, but me-r rats used less glucose during restriction and more glucose and less lipid for energy during body weight recovery than me-c rats (P < 0.0001). Increased energy efficiency and the shift in utilization of glucose and fatty acids followed closely the effects of cyclic food restriction and meal feeding on mammary carcinogenesis.
引用
收藏
页码:1398 / 1405
页数:8
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