Catalytic carbonylation of functionalized diamines: Application to the core structure of DMP 323 and DMP 450

被引：20

作者：

Hylton, KG

Main, AD

McElwee-White, L ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

[2] Univ Florida, Ctr Catalysis, Gainesville, FL 32611 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 04期

关键词：

D O I：

10.1021/jo026816v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

W(CO)(6)-catalyzed carbonylation provides an alternative to phosgene or phosgene derivatives such as 1,1-carbonyldiimidazole (CDI) for the conversion of amines to ureas. As an illustration, the core structure of the HIV protease inhibitors DMP 323 and DMP 450 has been prepared by catalytic carbonylation of diamine intermediates from the original syntheses.

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页码：1615 / 1617

页数：3

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