Hydrophilic/hydrophobic patterned surfaces as templates for DNA arrays

被引：71

作者：

Gillmor, SD

Thiel, AJ

Strother, TC

Smith, LM

Lagally, MG

机构：

[1] Univ Wisconsin, Dept Mat Sci & Engn, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

LANGMUIR | 2000年 / 16卷 / 18期

关键词：

D O I：

10.1021/la991026a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Addressable DNA arrays are created by photopatterning self-assembled monolayers to form hydrophilic and hydrophobic regions on a gold surface. The hydrophilic regions aid to contain small volumes of different DNA solutions placed on them using an automated pin-tool loading strategy. The method allows for efficient attachment, manipulation, and hybridization of pure DNA strands on the surface.

引用

页码：7223 / 7228

页数：6

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