Desensitisation of adrenomedullin and CGRP receptors

被引：27

作者：

Hay, DL

Poyner, DR

Smith, DM

机构：

[1] Hammersmith Hosp, Dept Metab Med, Imperial Coll, Sch Med, London W12 0NN, England

[2] Aston Univ, Sch Life Sci, Birmingham B4 7ET, W Midlands, England

来源：

REGULATORY PEPTIDES | 2003年 / 112卷 / 1-3期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

adrenomedullin; CGRP; RAMP; CRLR; rat-2; fibroblast; desensitisation;

D O I：

10.1016/S0167-0115(03)00032-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level. In this article, we discuss the few studies that have been presented on the desensitisation of AM receptors and also present novel data on the desensitisation of endogenous AM receptors in Rat-2 fibroblasts. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：139 / 145

页数：7

共 35 条

[31] ADRENOMEDULLIN STIMULATES 2 SIGNAL-TRANSDUCTION PATHWAYS, CAMP ACCUMULATION AND CA2+ MOBILIZATION, IN BOVINE AORTIC ENDOTHELIAL-CELLS [J].