Adiponectin, obesity, and cardiovascular disease

被引：96

作者：

Fasshauer, M ^{[1
]}

Paschke, R ^{[1
]}

Stumvoll, M ^{[1
]}

机构：

[1] Univ Leipzig, Dept Internal Med 3, D-04103 Leipzig, Germany

来源：

BIOCHIMIE | 2004年 / 86卷 / 11期

关键词：

adiponectin; cardiovascular disease; diabetes mellitus; insulin resistance; obesity; vascular dysfunction;

D O I：

10.1016/j.biochi.2004.09.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several adipocyte-secreted factors have been demonstrated to potentially link obesity, insulin resistance, and cardiovascular disease. Among those, adiponectin is an insulin-sensitizing and anti-inflammatory adipokine, concentrations of which are decreased in obesity-associated metabolic and vascular disorders. Recently, two adiponectin receptors (AdipoR) have been isolated and adenosine monophosphate kinase (AMPK), as well as acetyl coenzyme A carboxylase (ACC), appear to be critical downstream mediators for various effects of this adipokine. In addition to beneficial metabolic effects, adiponectin seems to be vasoprotective by interfering with various atherogenic processes. Of clinical interest, thiazolidinediones (TZDs) which are used in the treatment of type 2 diabetes stimulate adiponectin expression and secretion whereas several hormones dysregulated in insulin resistance and obesity downregulate this adipokine. The current knowledge on regulation and function of adiponectin in obesity, insulin resistance, and cardiovascular disease is summarized in this review and its clinical implications are discussed. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：779 / 784

页数：6

共 61 条

[1] Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Maeda, K ;

Kuriyama, H ;

Okamoto, Y ;

Kumada, M ;

Hotta, K ;

Nishida, M ;

Takahashi, M ;

Nakamura, T ;

Shimomura, I ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

CIRCULATION, 2002, 105 (24) :2893-2898

[2] The adipocyte-secreted protein Acrp30 enhances hepatic insulin action [J].

Berg, AH ;

Combs, TP ;

Du, XL ;

Brownlee, M ;

Scherer, PE .

NATURE MEDICINE, 2001, 7 (08) :947-953

[3] Adiponectin stimulates production of nitric oxide in vascular endothelial cells [J].

Chen, H ;

Montagnani, M ;

Funahashi, T ;

Shimomura, I ;

Quon, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (45) :45021-45026

[4] A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity [J].

Combs, TP ;

Pajvani, UB ;

Berg, AH ;

Lin, Y ;

Jelicks, LA ;

Laplante, M ;

Nawrocki, AR ;

Rajala, MW ;

Parlow, AF ;

Cheeseboro, L ;

Ding, YY ;

Russell, RG ;

Lindemann, D ;

Hartley, A ;

Baker, GRC ;

Obici, S ;

Deshaies, Y ;

Ludgate, M ;

Rossetti, L ;

Scherer, PE .

ENDOCRINOLOGY, 2004, 145 (01) :367-383

[5]

Combs TP, 2002, ENDOCRINOLOGY, V143, P998, DOI 10.1210/endo.143.3.8662

[6] Pre- and post-translational negative effect of β-adrenoceptor agonists on adiponectin secretion:: in vitro and in vivo studies [J].

Delporte, ML ;

Funahashi, T ;

Takahashi, M ;

Matsuzawa, Y ;

Brichard, SM .

BIOCHEMICAL JOURNAL, 2002, 367 (03) :677-685

[7]

Fan Jianglin, 2003, J Atheroscler Thromb, V10, P63

[8] Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes [J].

Fasshauer, M ;

Klein, J ;

Kralisch, S ;

Klier, M ;

Lössner, U ;

Blüher, M ;

Paschke, R .

FEBS LETTERS, 2004, 558 (1-3) :27-32

[9] Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes [J].

Fasshauer, M ;

Kralisch, S ;

Klier, M ;

Lossner, U ;

Bluher, M ;

Klein, J ;

Paschke, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (04) :1045-1050

[10] Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes [J].

Fasshauer, M ;

Klein, J ;

Neumann, S ;

Eszlinger, M ;

Paschke, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 290 (03) :1084-1089

← 1 2 3 4 5 6 7 →