Adiponectin, obesity, and cardiovascular disease

被引：96

作者：

Fasshauer, M ^{[1
]}

Paschke, R ^{[1
]}

Stumvoll, M ^{[1
]}

机构：

[1] Univ Leipzig, Dept Internal Med 3, D-04103 Leipzig, Germany

来源：

BIOCHIMIE | 2004年 / 86卷 / 11期

关键词：

adiponectin; cardiovascular disease; diabetes mellitus; insulin resistance; obesity; vascular dysfunction;

D O I：

10.1016/j.biochi.2004.09.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several adipocyte-secreted factors have been demonstrated to potentially link obesity, insulin resistance, and cardiovascular disease. Among those, adiponectin is an insulin-sensitizing and anti-inflammatory adipokine, concentrations of which are decreased in obesity-associated metabolic and vascular disorders. Recently, two adiponectin receptors (AdipoR) have been isolated and adenosine monophosphate kinase (AMPK), as well as acetyl coenzyme A carboxylase (ACC), appear to be critical downstream mediators for various effects of this adipokine. In addition to beneficial metabolic effects, adiponectin seems to be vasoprotective by interfering with various atherogenic processes. Of clinical interest, thiazolidinediones (TZDs) which are used in the treatment of type 2 diabetes stimulate adiponectin expression and secretion whereas several hormones dysregulated in insulin resistance and obesity downregulate this adipokine. The current knowledge on regulation and function of adiponectin in obesity, insulin resistance, and cardiovascular disease is summarized in this review and its clinical implications are discussed. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：779 / 784

页数：6

共 61 条

[21] Adipose tissue as an endocrine organ [J].

Kershaw, EE ;

Flier, JS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2548-2556

[22] Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin [J].

Kobayashi, H ;

Ouchi, N ;

Kihara, S ;

Walsh, K ;

Kumada, M ;

Abe, Y ;

Funahashi, T ;

Matsuzawa, Y .

CIRCULATION RESEARCH, 2004, 94 (04) :E27-E31

[23] Disruption of adiponectin causes insulin resistance and neointimal formation. [J].

Kubota, N ;

Terauchi, Y ;

Yamauchi, T ;

Kubota, T ;

Moroi, M ;

Matsui, J ;

Eto, K ;

Yamashita, T ;

Kamon, J ;

Satoh, H ;

Yano, W ;

Froguel, P ;

Nagai, R ;

Kimura, S ;

Kadowaki, T ;

Noda, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (29) :25863-25866

[24] Increased β-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin [J].

Ma, K ;

Cabrero, A ;

Saha, PK ;

Kojima, H ;

Li, L ;

Chang, BHJ ;

Paul, A ;

Chan, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (38) :34658-34661

[25] CDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (Adipose most abundant gene transcript 1) [J].

Maeda, K ;

Okubo, K ;

Shimomura, I ;

Funahashi, T ;

Matsuzawa, Y ;

Matsubara, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 221 (02) :286-289

[26] Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 [J].

Maeda, N ;

Shimomura, I ;

Kishida, K ;

Nishizawa, H ;

Matsuda, M ;

Nagaretani, H ;

Furuyama, N ;

Kondo, H ;

Takahashi, M ;

Arita, Y ;

Komuro, R ;

Ouchi, N ;

Kihara, S ;

Tochino, Y ;

Okutomi, K ;

Horie, M ;

Takeda, S ;

Aoyama, T ;

Funahashi, T ;

Matsuzawa, Y .

NATURE MEDICINE, 2002, 8 (07) :731-737

[27] PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein [J].

Maeda, N ;

Takahashi, M ;

Funahashi, T ;

Kihara, S ;

Nishizawa, H ;

Kishida, K ;

Nagaretani, H ;

Matsuda, M ;

Komuro, R ;

Ouchi, N ;

Kuriyama, H ;

Hotta, K ;

Nakamura, T ;

Shimomura, I ;

Matsuzawa, Y .

DIABETES, 2001, 50 (09) :2094-2099

[28] Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA [J].

Makimura, H ;

Mizuno, TM ;

Bergen, H ;

Mobbs, CV .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 283 (06) :E1266-E1271

[29] A transgenic model of visceral obesity and the metabolic syndrome [J].

Masuzaki, H ;

Paterson, J ;

Shinyama, H ;

Morton, NM ;

Mullins, JJ ;

Seckl, JR ;

Flier, JS .

SCIENCE, 2001, 294 (5549) :2166-2170

[30] Role of adiponectin in preventing vascular stenosis - The missing link of adipo-vascular axis [J].

Matsuda, M ;

Shimomura, I ;

Sata, M ;

Arita, Y ;

Nishida, M ;

Maeda, N ;

Kumada, M ;

Okamoto, Y ;

Nagaretani, H ;

Nishizawa, H ;

Kishida, K ;

Komuro, R ;

Ouchi, N ;

Kihara, S ;

Nagai, R ;

Funahashi, T ;

Matsuzawa, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (40) :37487-37491

← 1 2 3 4 5 6 7 →