4-dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1H-pyrazol-4-yl)butan-1-ols:: synthesis and evaluation of analgesic, anti-inflammatory and platelet anti-aggregating activities

被引：7

作者：

Menozzi, G

Mosti, L

Merello, L

Piana, A

Armani, U

Ghia, M

Angiola, M

Mattioli, F

机构：

[1] Univ Genoa, Dipartimento Sci Farmaceut, I-16132 Genoa, Italy

[2] Univ Genoa, Ctr Ric Trombosi, Dipartimento Med Interna, I-16132 Genoa, Italy

[3] Univ Genoa, Sez Farmacol, Dipartimento Med Interna, I-16132 Genoa, Italy

[4] Univ Genoa, Tossicol Clin, I-16132 Genoa, Italy

来源：

FARMACO | 2000年 / 55卷 / 03期

关键词：

pyrazole derivatives; anti-inflammatory agents; analgesic agents; platelet anti-aggregating agents;

D O I：

10.1016/S0014-827X(00)00007-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A number of 4-dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1H-pyrazol-4-yl)butan-1-ols 2a-n were synthesized and tested in vivo for anti-inflammatory and analgesic activities and in vitro for platelet anti-aggregating activity. Dimethyl-aminoderivatives 2b, e, g showed good analgesic activity; almost all of them had strong platelet anti-aggregating properties at a final concentration of 1 x 10(-3) M; pyrazoles 2c, d, f-h showed weak anti-inflammatory activity. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：219 / 226

页数：8

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