Immunology of human endometrium

被引:48
作者
Kämmerer, U
von Wolff, M
Markert, UR
机构
[1] Univ Jena, Abt Geburtshilfe, D-07740 Jena, Germany
[2] Univ Frauenklin Heidelberg, Gynakol Endokrinol & Fertilitatsstorungen, Heidelberg, Germany
[3] Univ Wurzburg, Frauneklin, Wurzburg, Germany
关键词
pregnancy; decidua; dendritic cells; T cells; NK cells; signal transduction;
D O I
10.1016/j.imbio.2004.04.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In pregnancy, the endometrium represents the hosting surface for invading semi-allogeneic cells. A very fine tuning of cellular interactions is indispensible for the successful symbiosis of mother and fetus. Such interactions include a variety of immune cells, which are present in extremely high concentrations, and trophoblast cells. A wide spectrum of soluble and surface molecules is involved in homing, activation and switching of lymphocyte functions, but also in regulation of embryo implantation and control of trophoblast invasion. This mini-review provides a brief overview of immunological features of the endometrium. (C) 2004 Elsevier GmbH. All rights reserved.
引用
收藏
页码:569 / 574
页数:6
相关论文
共 43 条
[11]   SIGNALING THROUGH THE HEMATOPOIETIC CYTOKINE RECEPTORS [J].
IHLE, JN ;
WITTHUHN, BA ;
QUELLE, FW ;
YAMAMOTO, K ;
SILVENNOINEN, O .
ANNUAL REVIEW OF IMMUNOLOGY, 1995, 13 :369-398
[12]  
KAMAT BR, 1987, AM J PATHOL, V127, P66
[13]   Human decidua contains potent immunostimulatory CD83+ dendritic cells [J].
Kämmerer, U ;
Schoppet, M ;
McLellan, AD ;
Kapp, M ;
Huppertz, HI ;
Kämpgen, E ;
Dietl, J .
AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (01) :159-169
[14]   Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy [J].
Kämmerer, U ;
Eggert, AO ;
Kapp, M ;
McLellan, AD ;
Geijtenbeek, TBH ;
Dietl, J ;
van Kooyk, Y ;
Kämpgen, E .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (03) :887-896
[15]   Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system [J].
Kayisli, UA ;
Selam, B ;
Guzeloglu-Kayisli, O ;
Demir, R ;
Arici, A .
JOURNAL OF IMMUNOLOGY, 2003, 171 (05) :2305-2313
[16]   Cytokines, prostaglandins and parturition - A review [J].
Keelan, JA ;
Blumenstein, M ;
Helliwell, RJA ;
Sato, TA ;
Marvin, KW ;
Mitchell, MD .
PLACENTA, 2003, 24 :S33-S46
[17]   Cytokine control in human endometrium [J].
Kelly, RW ;
King, AE ;
Critchley, HOD .
REPRODUCTION, 2001, 121 (01) :3-19
[18]  
Kilic M, 1999, AM J REPROD IMMUNOL, V41, P61
[19]   Characteristic changes of large granular lymphocytes that strongly express CD56 in endometrium during the menstrual cycle and early pregnancy [J].
Kodama, T ;
Hara, T ;
Okamoto, E ;
Kusunoki, Y ;
Ohama, K .
HUMAN REPRODUCTION, 1998, 13 (04) :1036-1043
[20]   Alterations in the expression of homing-associated molecules at the maternal/fetal interface during the course of pregnancy [J].
Kruse, A ;
Martens, N ;
Fernekorn, U ;
Hallmann, R ;
Butcher, EC .
BIOLOGY OF REPRODUCTION, 2002, 66 (02) :333-345