Reproductive cloning conserves cellular senescence

被引：2

作者：

Sedivy, JM ^{[1
]}

机构：

[1] Brown Univ, Dept Biochem Mol Biol & Cell Biol, Providence, RI 02912 USA

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 06期

关键词：

D O I：

10.1038/ncb0603-495

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomere shortening resulting from genome replication can trigger cellular senescence. In this issue Clark et al. show that rates of telomere attrition and the consequent replicative potential of cells are conserved during replicative cloning. This implies that these traits are genetically determined and raises interesting questions about their relationship to organismal phenotypes such as cancer, organ failure and ageing.

引用

页码：495 / 496

页数：3

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