Viruses as vaccine vectors for infectious diseases and cancer

被引：260

作者：

Draper, Simon J. ^{[1
]}

Heeney, Jonathan L. ^{[2
]}

机构：

[1] Univ Oxford, Jenner Inst, Oxford OX3 7DQ, England

[2] Univ Cambridge, Dept Vet Med, Lab Viral Zoonot, Cambridge CB3 0ES, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

T-CELL RESPONSES; PRIME-BOOST REGIMENS; BACTERIAL ARTIFICIAL CHROMOSOME; BACILLE CALMETTE-GUERIN; AVIAN INFLUENZA-VIRUS; IMMUNE-RESPONSES; ADENOVIRUS VECTORS; TUBERCULOSIS VACCINE; DENDRITIC CELLS; RHESUS-MONKEYS;

D O I：

10.1038/nrmicro2240

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent developments in the use of viruses as vaccine vectors have been facilitated by a better understanding of viral biology. Advances occur as we gain greater insight into the interrelationship of viruses and the immune system. Viral-vector vaccines remain the best means to induce cellular immunity and are now showing promise for the induction of strong humoral responses. The potential benefits for global health that are offered by this field reflect the scope and utility of viruses as vaccine vectors for human and veterinary applications, with targets ranging from certain types of cancer to a vast array of infectious diseases.

引用

收藏

页码：62 / 73

页数：12

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