Selective hydroformylation of N-allylacetamide in an inverted aqueous two-phase catalytic system, enabling a short synthesis of melatonin

被引：39

作者：

Verspui, G ^{[1
]}

Elbertse, G ^{[1
]}

Sheldon, FA ^{[1
]}

Hacking, MAPJ ^{[1
]}

Sheldon, RA ^{[1
]}

机构：

[1] Delft Univ Technol, Organ Chem & Catalysis Lab, NL-2628 BL Delft, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 15期

关键词：

D O I：

10.1039/b003715j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water increases the selectivity in the Rh-phosphine catalysed hydroformylation of N-allylacetamide; an aqueous-organic biphasic system, containing a hydrophobic Rh-catalyst, provided facile catalyst/product separation, after which the aqueous product phase could be used in a one-pot synthesis of N-acetyl-5-methoxytryptamine (melatonin).

引用

页码：1363 / 1364

页数：2