Somatosensory evoked fast optical intensity changes detected non-invasively in the adult human head

被引：84

作者：

Steinbrink, J

Kohl, M

Obrig, H

Curio, G

Syré, F

Thomas, F

Wabnitz, H

Rinneberg, H

Villringer, A

机构：

[1] Humboldt Univ, Charite, Neurol Klin, D-10098 Berlin, Germany

[2] Phys Tech Bundesanstalt, D-10587 Berlin, Germany

[3] Free Univ Berlin, UKBF, Abt Neurol, D-12200 Berlin, Germany

来源：

NEUROSCIENCE LETTERS | 2000年 / 291卷 / 02期

关键词：

near infrared spectroscopy; fast optical signals; event related optical signals; optical imaging; event related intensity change;

D O I：

10.1016/S0304-3940(00)01395-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This work is the first to report optical intensity changes (Delta I/I approximate to 0.05%) with a latency between 60 and 160ms after electrical median nerve stimulation at 5 Hz detected non-invasively through the intact adult human skull in volunteers. The signal is localised and reproducible when measuring at the same position on successive examinations. Compared to previous reports of fast optical changes in the human adult by a single group (Psychophysiology, 32 (1995) 505) the here reported changes are much smaller. They are in line with results from a photon transport calculation on a head model employing data from exposed cortical tissue. The origin of the signal found here is still unclear, however, they might be the non-invasive equivalent to the scattering changes found in exposed cortical tissue studies (J. Neurophysiol., 78 (1997) 1707). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：105 / 108

页数：4

共 17 条

[1] Intrinsic optical signal measurements reveal characteristic features during different forms of spontaneous neuronal hyperactivity associated with ECS shrinkage in vitro [J].