Peptide self-assembly as a model of proteins in the pre-genomic world

被引：32

作者：

Ghosh, I

Chrnielewski, J

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2004年 / 8卷 / 06期

基金：

美国国家航空航天局; 美国国家科学基金会;

关键词：

D O I：

10.1016/j.cbpa.2004.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Excellent catalytic efficiency has been obtained within a series of self replicating peptides, and nucleobase inclusion into a salt-switchable self replicating peptide is found to override the switch. Interestingly, cross-catalytic formation of an RNA aptamer is reported with a cationic peptide, and novel, amide-based biopolymers have been designed to self assemble.

引用

收藏

页码：640 / 644

页数：5

相关论文

共 39 条

[31] Synthesizing life [J].

Szostak, JW ;

Bartel, DP ;

Luisi, PL .

NATURE, 2001, 409 (6818) :387-390

[32] Construction of a chemically and conformationally self-replicating system of amyloid-like fibrils [J].

Takahashi, Y ;

Mihara, H .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (04) :693-699

[33]

von Kiedrowski G., 1993, BIOORG CHEM FRONT, P113

[34] A SELF-REPLICATING HEXADEOXYNUCLEOTIDE [J].

VONKIEDROWSKI, G .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1986, 25 (10) :932-935

[35] In vitro selection of functional nucleic acids [J].

Wilson, DS ;

Szostak, JW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :611-647

[36] A pH-modulated, self-replicating peptide [J].

Yao, S ;

Ghosh, I ;

Zutshi, R ;

Chmielewski, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (43) :10559-10560

[37] Deep penetration of an alpha-helix into a widened RNA major groove in the HIV-1 rev peptide-RNA aptamer complex [J].

Ye, XM ;

Gorin, A ;

Ellington, AD ;

Patel, DJ .

NATURE STRUCTURAL BIOLOGY, 1996, 3 (12) :1026-1033

[38] Amplification of diverse catalytic properties of evolving molecules in a simulated hydrothermal environment [J].

Yokoyama, S ;

Koyama, A ;

Nemoto, A ;

Honda, H ;

Imai, EI ;

Hatori, K ;

Matsuno, K .

ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES, 2003, 33 (06) :589-595

[39] AUTOCATALYTIC SYNTHESIS OF A TETRANUCLEOTIDE ANALOG [J].

ZIELINSKI, WS ;

ORGEL, LE .

NATURE, 1987, 327 (6120) :346-347

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