Towards stem-cell therapy in the endocrine pancreas

被引：38

作者：

Gangaram-Panday, Shanti T. ^{[1
]}

Faas, Marijke M. ^{[1
]}

de Vos, Paul ^{[1
]}

机构：

[1] Univ Groningen, Med Ctr, Dept Pathol & Lab Med, Sect Med Biol, NL-9713 GZ Groningen, Netherlands

来源：

TRENDS IN MOLECULAR MEDICINE | 2007年 / 13卷 / 04期

关键词：

D O I：

10.1016/j.molmed.2007.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many approaches of stem-cell therapy for the treatment of diabetes have been described. One is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell transplantation. During recent years three types of stem cells have been investigated: embryonic stem cells, bone-marrow-derived stem cells and organ-bound stem cells. We discuss the advantages and limitations of these different cell types. The applicability for the treatment of dysfunction of 0 cells in the pancreas has been demonstrated for all three cell types, but more-detailed understanding of the sequence of events during differentiation is required to produce fully functional insulin-producing cells.

引用

收藏

页码：164 / 173

页数：10

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