Towards stem-cell therapy in the endocrine pancreas

被引：38

作者：

Gangaram-Panday, Shanti T. ^{[1
]}

Faas, Marijke M. ^{[1
]}

de Vos, Paul ^{[1
]}

机构：

[1] Univ Groningen, Med Ctr, Dept Pathol & Lab Med, Sect Med Biol, NL-9713 GZ Groningen, Netherlands

来源：

TRENDS IN MOLECULAR MEDICINE | 2007年 / 13卷 / 04期

关键词：

D O I：

10.1016/j.molmed.2007.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many approaches of stem-cell therapy for the treatment of diabetes have been described. One is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell transplantation. During recent years three types of stem cells have been investigated: embryonic stem cells, bone-marrow-derived stem cells and organ-bound stem cells. We discuss the advantages and limitations of these different cell types. The applicability for the treatment of dysfunction of 0 cells in the pancreas has been demonstrated for all three cell types, but more-detailed understanding of the sequence of events during differentiation is required to produce fully functional insulin-producing cells.

引用

收藏

页码：164 / 173

页数：10

相关论文

共 79 条

[31] Activation of nestin-positive duct stem (NPDS) cells in pancreas upon neogenic motivation and possible cytodifferentiation into insulin-secreting cells from NPDS cells [J].

Kim, SY ;

Lee, SH ;

Kim, BM ;

Kim, EH ;

Min, BH ;

Bendayan, M ;

Park, IS .

DEVELOPMENTAL DYNAMICS, 2004, 230 (01) :1-11

[32] Islet regeneration during the reversal of autoimmune diabetes in NOD mice [J].

Kodama, S ;

Kühtreiber, W ;

Fujimura, S ;

Dale, EA ;

Faustman, DL .

SCIENCE, 2003, 302 (5648) :1223-1227

[33] NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice [J].

Kojima, H ;

Fujimiya, M ;

Matsumura, K ;

Younan, P ;

Imaeda, H ;

Maeda, M ;

Chan, L .

NATURE MEDICINE, 2003, 9 (05) :596-603

[34] Committing embryonic stem cells to early endocrine pancreas in vitro [J].

Ku, HT ;

Zhang, N ;

Kubo, A ;

O'Connor, R ;

Mao, MW ;

Keller, G ;

Bromberg, JS .

STEM CELLS, 2004, 22 (07) :1205-1217

[35] No evidence for significant transdifferentiation of bone marrow into pancreatic β-cells in vivo [J].

Lechner, A ;

Yang, YG ;

Blacken, RA ;

Wang, L ;

Nolan, AL ;

Habener, JF .

DIABETES, 2004, 53 (03) :616-623

[36] Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter [J].

Lechner, A ;

Leech, CA ;

Abraham, EJ ;

Nolan, AL ;

Habener, JF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 293 (02) :670-674

[37] Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1α knockout mouse [J].

Lee, YH ;

Sauer, B ;

Gonzalez, FJ .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) :3059-3068

[38] In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells [J].

León-Quinto, T ;

Jones, J ;

Skoudy, A ;

Burcin, M ;

Soria, B .

DIABETOLOGIA, 2004, 47 (08) :1442-1451

[39] In vitro transdifferentiation of hepatoma cells into functional pancreatic cells [J].

Li, WC ;

Horb, ME ;

Tosh, D ;

Slack, JMW .

MECHANISMS OF DEVELOPMENT, 2005, 122 (06) :835-847

[40]

Liu Tao, 2004, J Huazhong Univ Sci Technolog Med Sci, V24, P464

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