Thioredoxin peroxidase is required for the transcriptional response to oxidative stress in budding yeast

被引：96

作者：

Ross, SJ ^{[1
]}

Findlay, VJ ^{[1
]}

Malakasi, P ^{[1
]}

Morgan, BA ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Sch Med, Sch Biochem & Genet, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

MOLECULAR BIOLOGY OF THE CELL | 2000年 / 11卷 / 08期

关键词：

D O I：

10.1091/mbc.11.8.2631

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A genetic screen was performed in Saccharomyces cerevisiae to identify mechanisms important for the transcriptional activation of genes encoding antioxidant proteins. Thioredoxin peroxidase, Tsa1p, of the thioredoxin system, was found to be essential for the transcriptional induction of other components of the thioredoxin system, TRX2 (thioredoxin) and TRR1 (thioredoxin reductase), in response to H2O2. The expression of TRX2 and TRR1 is known to be regulated by the transcription factors Yap1p and Skn7p in response to H2O2, and the Tsa1p-dependent regulation of TRX2 requires the Yap1p/Skn7p pathway. The data suggest that expression of components of the thioredoxin system is dependent on the activity of Tsa1p in response to H2O2 in a Yap1p/Skn7p-dependent pathway.

引用

页码：2631 / 2642

页数：12

共 32 条

[1] Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein β subunits and the yeast response regulator protein Skn7 [J].