Role of SNP/haplotype map in gene discovery and drug development: An overview

Recent advances in genomics provide an opportunity to understand a detailed history of human genes and common diseases, and to predict the effectiveness and safety of medications for each individual. In order to accomplish this goal, it is thought that a high-density map of single nucleotide polymorphism (SNP) of the human genome is needed. By comparing SNIP patterns in various patients and control populations, it may be possible to identify unique variants that predispose to disease and predict the effectiveness of drug therapy. But it will take a considerable amount of time and effort to develop new medicines. Additionally, diagnostic application of variants in clinics requires an understanding of their functional significance and appropriate clinical studies. Moreover, it is important that this rapidly developing genome information be incorporated in the continuing education of medical professionals so that the results of basic research can be translated to the welfare of patients. (C) 2004 Wiley-Liss, Inc.