Effect of ashwagandha on lipid peroxidation in stress-induced animals

被引：99

作者：

Dhuley, JN ^{[1
]}

机构：

[1] Hindustan Antibiot Ltd, Dept Pharmacol & Toxicol, Res Ctr, Pune 411018, Maharashtra, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1998年 / 60卷 / 02期

关键词：

ashwagandha; lipid peroxidation; lipopolysaccharide; peptidoglycan;

D O I：

10.1016/S0378-8741(97)00151-7

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

`The aqueous suspension of root extract of an Indian drug ashwagandha (Withania somnifera L. (Solanaceae)) was evaluated for its effect on lipid peroxidation (LPO) in stress-induced animals. Elevation of LPO was observed in rabbits and mice after intravenous administration of 0.2 mu g/kg of lipapolysaccharide (LPS: from Klebsiella pneumoniae) and 100 mu g/kg of peptidoglycan (PGN: from Staphylococcus aureus), respectively. The peak was reached immediately after PGN and 2-6 h after LPS administration. Simultaneous oral administration of ashwagandha (100 mg/kg) prevented the rise in LPO in rabbits and mice. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：173 / 178

页数：6

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