Building better mouse models of asthma

被引:41
作者
Lloyd, Clare M. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Leukocyte Biol Sect, Natl Heart & Lung Inst, Fac Med, London SW7 2AZ, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1007/s11882-007-0077-0
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Allergic asthma is a complex disease that has been modeled extensively in small rodents. Airway eosinophilia and changes in lung function have been documented using a variety of protocols. However, recent efforts have improved these models by trying to replicate the structural remodeling that occurs in the lung as a consequence of chronic allergen-driven inflammation. This review documents the recent developments in protocols and systems designed to examine pathways leading to allergen-induced airway remodeling.
引用
收藏
页码:231 / 236
页数:6
相关论文
共 39 条
[1]   Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium [J].
Broide, DH ;
Lawrence, T ;
Doherty, T ;
Cho, JY ;
Miller, M ;
McElwain, K ;
McElwain, S ;
Karin, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (49) :17723-17728
[2]   Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism [J].
Cates, EC ;
Fattouh, R ;
Wattie, J ;
Inman, MD ;
Goncharova, S ;
Coyle, AJ ;
Gutierrez-Ramos, JC ;
Jordana, M .
JOURNAL OF IMMUNOLOGY, 2004, 173 (10) :6384-6392
[3]   Inhibition of airway remodeling in IL-5-deficient mice [J].
Cho, JY ;
Miller, M ;
Baek, KJ ;
Han, JW ;
Nayar, J ;
Lee, SY ;
McElwain, K ;
McElwain, S ;
Friedman, S ;
Broide, DH .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (04) :551-560
[4]  
Elias Jack, 2004, Chest, V126, p111S, DOI 10.1378/chest.126.2_suppl_1.111S
[5]   House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation [J].
Fattouh, R ;
Pouladi, MA ;
Alvarez, D ;
Johnson, JR ;
Walker, TD ;
Goncharova, S ;
Inman, MD ;
Jordana, M .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 172 (03) :314-321
[6]   Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet [J].
Finotto, S ;
Neurath, MF ;
Glickman, JN ;
Qin, SX ;
Lehr, HA ;
Green, FHY ;
Ackerman, K ;
Haley, K ;
Gatte, PR ;
Szabo, SJ ;
Drazen, JM ;
De Sanctis, GT ;
Glimcher, LH .
SCIENCE, 2002, 295 (5553) :336-338
[7]   Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma [J].
Foster, PS ;
Webb, DC ;
Yang, M ;
Herbert, C ;
Kumar, RK .
CLINICAL AND EXPERIMENTAL ALLERGY, 2003, 33 (05) :688-695
[8]   A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model [J].
Henderson, WR ;
Tang, LO ;
Chu, SJ ;
Tsao, SM ;
Chiang, GKS ;
Jones, F ;
Jonas, M ;
Pae, C ;
Wang, HJ ;
Chi, EY .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (01) :108-116
[9]   The importance of leukotrienes in airway inflammation in a mouse model of asthma [J].
Henderson, WR ;
Lewis, DB ;
Albert, RK ;
Zhang, Y ;
Lamm, WJE ;
Chiang, GKS ;
Jones, F ;
Eriksen, P ;
Tien, YT ;
Jonas, M ;
Chi, EY .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (04) :1483-1494
[10]   A critical role for eosinophils in allergic airways remodeling [J].
Humbles, AA ;
Lloyd, CM ;
McMillan, SJ ;
Friend, DS ;
Xanthou, G ;
McKenna, EE ;
Ghiran, S ;
Gerard, NP ;
Yu, CN ;
Orkin, SH ;
Gerard, C .
SCIENCE, 2004, 305 (5691) :1776-1779