Modern Determination of Complement Activation

被引：13

作者：

Oppermann, Martin ^{[1
]}

Wuerzner, Reinhard ^{[1
]}

机构：

[1] Zentrum Hyg & Humangenet, Abt Zellulare & Mol Immunol, D-37075 Gottingen, Germany

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2010年 / 36卷 / 06期

关键词：

Complement activation; quantitation; ELISA; monoclonal antibodies; neoepitope; native restricted; MONOCLONAL-ANTIBODIES; PLASMA-LEVELS; MACULAR DEGENERATION; ALTERNATIVE PATHWAY; RENAL-FAILURE; INHIBITOR COMPLEXES; SANDWICH-ELISA; FRAGMENT-BA; QUANTITATION; NEOEPITOPE;

D O I：

10.1055/s-0030-1262882

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Modern, that is, accurate determination of complement activation in vivo requires the simultaneous determination of both naive and activated complement proteins. This is best achieved by the use of native-restricted and neoepitope-specific monoclonal antibodies in sensitive enzyme-linked immunosorbent assays. Several confounding factors also have to be taken into account to allow a correct interpretation of the results.

引用

页码：611 / 619

页数：9

共 59 条

[1] MONOCLONAL-ANTIBODIES AGAINST COMPLEMENT-3 NEOANTIGENS FOR DETECTION OF IMMUNE-COMPLEXES AND COMPLEMENT ACTIVATION - RELATIONSHIP BETWEEN IMMUNE-COMPLEX LEVELS, STATE OF C-3, AND NUMBERS OF RECEPTORS FOR C3B [J].

AGUADO, MT ;

LAMBRIS, JD ;

TSOKOS, GC ;

BURGER, R ;

BITTERSUERMANN, D ;

TAMERIUS, JD ;

DIXON, FJ ;

THEOFILOPOULOS, AN .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (04) :1418-1426

[2] COMPLEMENT DEFICIENCY - PREDISPOSING FACTOR TO AUTOIMMUNE SYNDROMES [J].

ATKINSON, JP .

AMERICAN JOURNAL OF MEDICINE, 1988, 85 (6A) :45-47

[3] PRODUCTION OF MONOCLONAL-ANTIBODIES AGAINST THE HUMAN ANAPHYLATOXIN-C5A DES ARG AND THEIR APPLICATION IN THE NEOEPITOPE-SPECIFIC SANDWICH-ELISA FOR THE QUANTIFICATION OF C5A DES ARG IN PLASMA [J].

BERGH, K ;

IVERSEN, OJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 1992, 152 (01) :79-87

[4] SERUM COMPLEMENT VALUES (C-3 AND C-4) TO DIFFERENTIATE BETWEEN SYSTEMIC LUPUS ACTIVITY AND PREECLAMPSIA [J].

BUYON, JP ;

CRONSTEIN, BN ;

MORRIS, M ;

TANNER, M ;

WEISSMANN, G .

AMERICAN JOURNAL OF MEDICINE, 1986, 81 (02) :194-200

[5]

Chenoweth D E, 1987, Contrib Nephrol, V59, P51

[6] HEMODIALYSIS LEUKOPENIA - PULMONARY VASCULAR LEUKOSTASIS RESULTING FROM COMPLEMENT ACTIVATION BY DIALYZER CELLOPHANE MEMBRANES [J].

CRADDOCK, PR ;

FEHR, J ;

DALMASSO, AP ;

BRIGHAM, KL ;

JACOB, HS .

JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (05) :879-888

[7] PLASMA-LEVELS OF C1 INHIBITOR COMPLEXES AND CLEAVED C1 INHIBITOR IN PATIENTS WITH HEREDITARY ANGIONEUROTIC-EDEMA [J].

CUGNO, M ;

NUIJENS, J ;

HACK, E ;

EERENBERG, A ;

FRANGI, D ;

AGOSTONI, A ;

CICARDI, M .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (04) :1215-1220

[8] Mechanisms of disease: Age-related macular degeneration [J].

de Jong, Paulus T. V. M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (14) :1474-1485

[9] FLUID PHASE GENERATION OF TERMINAL COMPLEMENT COMPLEX AS A NOVEL INDEX OF BIOINCOMPATIBILITY [J].

DEPPISCH, R ;

SCHMITT, V ;

BOMMER, J ;

HANSCH, GM ;

RITZ, E ;

RAUTERBERG, EW .

KIDNEY INTERNATIONAL, 1990, 37 (02) :696-706

[10] Genetic and environmental factors influencing the human factor H plasma levels [J].

Esparza-Gordillo, J ;

Soria, JM ;

Buil, A ;

Almasy, L ;

Blangero, J ;

Fontcuberta, J ;

de Córdoba, SR .

IMMUNOGENETICS, 2004, 56 (02) :77-82

← 1 2 3 4 5 6 →