Modern Determination of Complement Activation

被引：13

作者：

Oppermann, Martin ^{[1
]}

Wuerzner, Reinhard ^{[1
]}

机构：

[1] Zentrum Hyg & Humangenet, Abt Zellulare & Mol Immunol, D-37075 Gottingen, Germany

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2010年 / 36卷 / 06期

关键词：

Complement activation; quantitation; ELISA; monoclonal antibodies; neoepitope; native restricted; MONOCLONAL-ANTIBODIES; PLASMA-LEVELS; MACULAR DEGENERATION; ALTERNATIVE PATHWAY; RENAL-FAILURE; INHIBITOR COMPLEXES; SANDWICH-ELISA; FRAGMENT-BA; QUANTITATION; NEOEPITOPE;

D O I：

10.1055/s-0030-1262882

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Modern, that is, accurate determination of complement activation in vivo requires the simultaneous determination of both naive and activated complement proteins. This is best achieved by the use of native-restricted and neoepitope-specific monoclonal antibodies in sensitive enzyme-linked immunosorbent assays. Several confounding factors also have to be taken into account to allow a correct interpretation of the results.

引用

页码：611 / 619

页数：9

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