Comparison of inhibitory effects of local anesthetics on immune functions of neutrophils

被引：50

作者：

Azuma, Y ^{[1
]}

Shinohara, M ^{[1
]}

Wang, PL ^{[1
]}

Suese, Y ^{[1
]}

Yasuda, H ^{[1
]}

Ohura, K ^{[1
]}

机构：

[1] Osaka Dent Univ, Dept Pharmacol, Osaka 5731121, Japan

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 2000年 / 22卷 / 10期

关键词：

local anesthetics; neutrophil; adhesion; phagocytosis; superoxide anion; hydrogen peroxide;

D O I：

10.1016/S0192-0561(00)00040-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunological effects of a variety of local anesthetics on adhesion, phagocytosis, and the production of superoxide anion and hydrogen peroxide by neutrophils were compared. Neutrophils were isolated by peritoneal lavage From rats, 4 h after injection of 1% glycogen. Lidocaine, mepivacaine, procaine, prilocaine and tetracaine at 1 mg/ml inhibited adhesion, phagocytosis, and the production of superoxide anion and hydrogen peroxide in neutrophils. Moreover, lidocaine, mepivacaine, procaine and prilocaine at 0.1 mg/ml inhibited the production of superoxide anion and hydrogen peroxide but not adhesion or phagocytosis. In contrast, tetracaine at 0.1 mg/ml inhibited phagocytosis, and the production of superoxide anion and hydrogen peroxide but not adhesion. Al 0.01 mg/ml, however, tetracaine inhibited the production of superoxide anion and hydrogen peroxide; in contrast, other drugs Failed to affect neutrophil function. These results suggest that the local anesthetics may affect adhesion, phagocytosis, and the production of superoxide anion and hydrogen peroxide by neutrophils. (C) 2000 International Society for Immunopharmacology. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：789 / 796

页数：8

共 26 条

[21] QUANTITATIVE STUDIES OF PHAGOCYTOSIS BY POLYMORPHONUCLEAR LEUKOCYTES - USE OF EMULSIONS TO MEASURE INITIAL RATE OF PHAGOCYTOSIS [J].