The diversity, structure and regulation of β-lactamases

被引:57
作者
Philippon, A
Dusart, J
Joris, B
Frère, JM
机构
[1] Univ Liege, Ctr Ingn Prot, Inst Chim B6, B-4000 Liege, Belgium
[2] Univ Paris 07, Hop Cochin, Serv Bacteriol, F-75475 Paris 14, France
关键词
beta-lactamases; penicillins; cephalosporins; regulation; classification;
D O I
10.1007/s000180050161
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
beta-Lactamase production is responsible for the appearance of a large number of pathogenic bacterial strains exhibiting a high degree of resistance to beta-lactam antibiotics. A large number of enzymes have been described with very diverse primary structures and catalytic profiles. Nevertheless, all known three-dimensional structures of active-site serine beta-lactamases exhibit a high degree of similarity with apparently equivalent chemical functionalities in the same strategic positions. These groups might not, however, play identical roles in the various classes of enzymes. Structural data have also been recently obtained for the zinc metallo-beta-lactamases, but the detailed catalytic mechanisms might also differ widely, depending on the enzyme studied. Similarly, the induction of the synthesis of beta-lactamases is now better understood, but many questions remain to be answered.
引用
收藏
页码:341 / 346
页数:6
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