The Cyclic Dipeptide Cyclo(Phe-Pro) Inhibits Cholera Toxin and Toxin-Coregulated Pilus Production in O1 El Tor Vibrio cholerae

被引：29

作者：

Bina, Xiaowen R. ^{[1
]}

Bina, James E. ^{[1
]}

机构：

[1] Univ Tennessee, Dept Mol Sci, Hlth Sci Ctr, Memphis, TN 38163 USA

来源：

JOURNAL OF BACTERIOLOGY | 2010年 / 192卷 / 14期

关键词：

VIRULENCE FACTOR PRODUCTION; TRANSCRIPTIONAL ACTIVATORS; EXPRESSION; CASCADE; APHA; REGULATOR; PROMOTER; LEVEL; VECTOR; FAMILY;

D O I：

10.1128/JB.00191-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cyclo(Phe-Pro) is a cyclic dipeptide produced by multiple Vibrio species. In this work, we present evidence that cyclo(Phe-Pro) inhibits the production of the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) in O1 El Tor Vibrio cholerae strain N16961 during growth under virulence gene-inducing conditions. The cyclo(Phe-Pro) inhibition of CT and TCP production correlated with reduced transcription of the virulence regulator tcpPH and was alleviated by overexpression of tcpPH.

引用

页码：3829 / 3832

页数：4

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