Barbier-type allylation of iminium ions generated in situ in aqueous medium

被引：51

作者：

Estevam, IHS

Bieber, LW

机构：

[1] Univ Fed Pernambuco, Dept Quim Fundamental, BR-50670901 Recife, PE, Brazil

[2] Univ Estado Bahia, Dept Ciencias Exatas & Terra, BR-40000000 Salvador, BA, Brazil

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 04期

关键词：

Barbier reaction; allylation; iminium salts; aqueous solvent;

D O I：

10.1016/S0040-4039(02)02667-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iminium ions, generated in aqueous solution from secondary amines and formaldehyde, undergo a Barbier-type allylation mediated by tin, aluminum and zinc, The reaction is catalyzed by copper and produces tertiary homoallylamines in up to 85% yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

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收藏

页码：667 / 670

页数：4

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