Cytosensor techniques for examining signal transduction of neurohormones

被引：19

作者：

Smart, D ^{[1
]}

Wood, MD ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Neurosci Res, Harlow CM19 5AW, Essex, England

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2000年 / 78卷 / 03期

关键词：

cytosensor; microphysiometry; signal transduction; neuropeptides; hormones;

D O I：

10.1139/bcb-78-3-281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes the principles of microphysiometry and how they can be applied, using the Cytosensor, to the investigation of the signal transduction mechanisms activated by both G-protein and non-a-protein coupled hormone and neuropeptide receptors. The use of the Cytosensor to study desensitisation and cross-talk is also discussed, as are the benefits and limitations of this technique.

引用

页码：281 / 288

页数：8

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