Genetic effects on ADHD symptomatology in 7- to 13- year-old twins: Results from a telephone survey

被引:76
作者
Nadder, TS
Silberg, JL
Eaves, LJ
Maes, HH
Meyer, JM
机构
[1] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Human Genet, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Dept Clin Lab Sci, Richmond, VA 23298 USA
关键词
attention-deficit hyperactivity disorder; genetics; twins; oppositional-defiant disorder; conduct disorder; contrast effects;
D O I
10.1023/A:1021686906396
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The magnitude of genetic and environmental factors and the influence of contrast effects on attention-deficit hyperactivity disorder (ADHD) symptomatology were examined on a sample of 900 twin pairs, aged 7-13, participating in the Virginia Twin Study of Adolescent Behavioral Development (VTSABD). In addition, the genetic and environmental correlations between ADHD and oppositional-defiant disorder/conduct disorder (ODD/CD) symptomatology were estimated. A series of structural models was applied to maternal ratings from a telephone survey, designed to screen for the three dimensions of ADHD symptomatology (hyperactivity, impulsivity, and inattention) and ODD/CD symptomatology. Model-fitting results suggested that ADHD symptomatology is highly heritable and influenced mostly by additive genetic, specific environmental, and contrast effects. However, this analysis could not exclude with statistical significance additional effects from dominance. The results of the best-fitting bivariate model suggested that the genetic correlation between the two traits is 50% and replicated previous findings of a common genetic factor influencing the comorbidity of ADHD and ODD/CD symptomatologies.
引用
收藏
页码:83 / 99
页数:17
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