Synthesis and metal-binding properties of chelating fluorescein derivatives

被引:41
作者
Clark, MA [1 ]
Duffy, K [1 ]
Tilbrewala, J [1 ]
Lippard, SJ [1 ]
机构
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
关键词
D O I
10.1021/ol0344570
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two routes to highly functionalized metal-chelating fluorescein derivatives have been pursued. Compound 3 is partially quenched by a variety of first-row transition metal ions in aqueous solution, with EC50 values ranging from 0.4 to 60 muM. Compounds of this type may find application in biological sensing.
引用
收藏
页码:2051 / 2054
页数:4
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