Synthesis and metal-binding properties of chelating fluorescein derivatives

被引：41

作者：

Clark, MA ^{[1
]}

Duffy, K ^{[1
]}

Tilbrewala, J ^{[1
]}

Lippard, SJ ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 12期

关键词：

D O I：

10.1021/ol0344570

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two routes to highly functionalized metal-chelating fluorescein derivatives have been pursued. Compound 3 is partially quenched by a variety of first-row transition metal ions in aqueous solution, with EC50 values ranging from 0.4 to 60 muM. Compounds of this type may find application in biological sensing.

引用

页码：2051 / 2054

页数：4

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