Genetic organization of the downstream region of the mecA element in methicillin-resistant Staphylococcus aureus isolates carrying different polymorphisms of this region

被引：51

作者：

Oliveira, DC

Wu, SW

de Lencastre, H

机构：

[1] Rockefeller Univ, Microbiol Lab, New York, NY 10021 USA

[2] Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Unit, P-2780 Oeiras, Portugal

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 07期

关键词：

D O I：

10.1128/AAC.44.7.1906-1910.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe here the genetic organization of the mec element downstream of the mecA gene in 34 different methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates carrying 13 of the most frequent polymorphisms of mecA and representing the major epidemic clones of MRSA. AII polymorphisms carried three common genetic elements: the hypervariable region, a copy of IS431, and a unique 2-kb sequence (downstream constant segment, or dcs) for which no homologous sequences are found in data banks. Polymorphisms of the downstream region were shown to be caused by the presence of linearized plasmids flanked by insertion sequences (pUB110 pT181, and pI258) and the autonomous insertion sequence IS256.

引用

页码：1906 / 1910

页数：5

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