Biotransformation of triptonide by cell suspension cultures of Platycodon grandifiorum

被引：7

作者：

Ning, LL

Guo, HZ

Jiang, XM

Bi, KS

Guo, D ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China

来源：

PURE AND APPLIED CHEMISTRY | 2003年 / 75卷 / 2-3期

关键词：

D O I：

10.1351/pac200375020389

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biotransformation of triptonide by cell suspension cultures of Platycodon grandiflorum was investigated. After six days of incubation, five products were obtained. On the basis of chemical and spectral evidence, their structures were elucidated as epitriptolide-14-O-beta-D-glucoside, 5alpha-hydroxytriptonide, triptolide, triptodiolide, and 2beta-hydroxytriptonide, among which epitriptolide-14-O-beta-D-glucoside and 5alpha-hydroxytriptonide are new compounds.

引用

页码：389 / 392

页数：4