Effector T cell plasticity: flexibility in the face of changing circumstances

被引：365

作者：

Murphy, Kenneth M. ^{[1
]}

Stockinger, Brigitta ^{[2
]}

机构：

[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 08期

关键词：

ARYL-HYDROCARBON RECEPTOR; FOLLICULAR-HELPER-CELLS; CXC CHEMOKINE RECEPTOR-5; TH17; CELLS; RETINOIC-ACID; ROR-GAMMA; IFN-GAMMA; TGF-BETA; IN-VIVO; LINEAGE DIFFERENTIATION;

D O I：

10.1038/ni.1899

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.

引用

页码：674 / 680

页数：7

共 111 条

[41] Chromatin modifications and their function
Kouzarides, Tony
[J]. CELL, 2007, 128 (04) : 693 - 705
[42] Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors
Kwon, Hyokjoon
Thierry-Mieg, Danielle
Thierry-Mieg, Jean
Kim, Hyoung-Pyo
Oh, Jangsuk
Tunyaplin, Chainarong
Carotta, Sebastian
Donovan, Colleen E.
Goldman, Matthew L.
Tailor, Prafullakumar
Ozato, Keiko
Levy, David E.
Nutt, Stephen L.
Calame, Kathryn
Leonard, Warren J.
[J]. IMMUNITY, 2009, 31 (06) : 941 - 952
[43] Late Developmental Plasticity in the T Helper 17 Lineage
Lee, Yun Kyung
Turner, Henrietta
Maynard, Craig L.
Oliver, James R.
Chen, Dongquan
Elson, Charles O.
Weaver, Casey T.
[J]. IMMUNITY, 2009, 30 (01) : 92 - 107
[44] Th memory for interleukin-17 expression is stable in vivo
Lexberg, Maria H.
Taubner, Annegret
Foerster, Anna
Albrecht, Inka
Richter, Anne
Kamradt, Thomas
Radbruch, Andreas
Chang, Hyun-Dong
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (10) : 2654 - 2664
[45] Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors
Loehning, Max
Hegazy, Ahmed N.
Pinschewer, Daniel D.
Busse, Dorothea
Lang, Karl S.
Hoefer, Thomas
Radbruch, Andreas
Zinkernagel, Rolf M.
Hengartner, Hans
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (01) : 53 - 61
[46] Mast cells are essential intermediaries in regulatory T-cell tolerance
Lu, Li-Fan
Lind, Evan F.
Gondek, David C.
Bennett, Kathy A.
Gleeson, Michael W.
Pino-Lagos, Karina
Scott, Zachary A.
Coyle, Anthony J.
Reed, Jennifer L.
Van Snick, Jacques
Strom, Terry B.
Zheng, Xin Xiao
Noelle, Randolph J.
[J]. NATURE, 2006, 442 (7106) : 997 - 1002
[47] INTERLEUKIN-12 INDUCES STABLE PRIMING FOR INTERFERON-GAMMA (IFN-GAMMA) PRODUCTION DURING DIFFERENTIATION OF HUMAN T-HELPER (TH) CELLS AND TRANSIENT IFN-GAMMA PRODUCTION IN ESTABLISHED TH2 CELL CLONES
MANETTI, R
GEROSA, F
GIUDIZI, MG
BIAGIOTTI, R
PARRONCHI, P
PICCINNI, MP
SAMPOGNARO, S
MAGGI, E
ROMAGNANI, S
TRINCHIERI, G
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (04) : 1273 - 1283
[48] Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals
Martin, Bruno
Hirota, Keiji
Cua, Daniel J.
Stockinger, Brigitta
Veldhoen, Marc
[J]. IMMUNITY, 2009, 31 (02) : 321 - 330
[49] Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming
Martín-Fontecha, A
Thomsen, LL
Brett, S
Gerard, C
Lipp, M
Lanzavecchia, A
Sallusto, F
[J]. NATURE IMMUNOLOGY, 2004, 5 (12) : 1260 - 1265
[50] Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
Martin-Orozco, Natalia
Chung, Yeonseok
Chang, Seon Hee
Wang, Yi-Hong
Dong, Chen
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (01) : 216 - 224

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