Optical properties of ocular fundus tissues determined by optical coherence tomography

被引:20
作者
Hammer, M [1 ]
Schweitzer, D [1 ]
Thamm, E [1 ]
Kolb, A [1 ]
机构
[1] Univ Jena, Dept Ophthalmol, D-07740 Jena, Germany
关键词
optical coherence tomography; ocular fundus; extinction coefficient; scattering anisotropy; refractive index;
D O I
10.1016/S0030-4018(00)01054-3
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Goal: To determine the extinction coefficient and the anisotropy of scattering as well as the refractive indices in the retina and in the choroid non-invasively in vivo. Method: The power of coherent reflected light versus fundus depth is recorded by optical coherence tomography (OCT). The ratio of the refractive indices is derived from the height of the reflection peaks. The extinction coefficient and anisotropy of scattering are calculated from the offset and the slope of the signal behind the reflection peaks. Results: Values similar to those known from in vitro measurements were found for the extinction coefficient and scattering anisotropy of the retina and the choroid. Conclusions: The OCT, usually employed for the measurement of intraocular distances and tomographic imaging, is capable to determine further interesting parameters of single ocular layers. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:149 / 153
页数:5
相关论文
共 18 条
[1]   SIGNAL AND RESOLUTION ENHANCEMENTS IN DUAL BEAM OPTICAL COHERENCE TOMOGRAPHY OF THE HUMAN EYE [J].
Baumgartner, Angela ;
Hitzenberger, Christoph K. ;
Sattmann, Harald ;
Drexler, Wolfgang ;
Fercher, Adolf F. .
JOURNAL OF BIOMEDICAL OPTICS, 1998, 3 (01) :45-54
[2]  
Brent R. P., 2002, Algorithms for Minimization without Derivatives
[3]   GUIDED-WAVE REFLECTOMETRY WITH MICROMETER RESOLUTION [J].
DANIELSON, BL ;
WHITTENBERG, CD .
APPLIED OPTICS, 1987, 26 (14) :2836-2842
[4]  
Fercher A F, 1996, J Biomed Opt, V1, P157, DOI 10.1117/12.231361
[5]   EYE-LENGTH MEASUREMENT BY INTERFEROMETRY WITH PARTIALLY COHERENT-LIGHT [J].
FERCHER, AF ;
MENGEDOHT, K ;
WERNER, W .
OPTICS LETTERS, 1988, 13 (03) :186-188
[6]   OPTICAL-PROPERTIES OF OCULAR FUNDUS TISSUES - AN IN-VITRO STUDY USING THE DOUBLE-INTEGRATING-SPHERE TECHNIQUE AND INVERSE MONTE-CARLO SIMULATION [J].
HAMMER, M ;
ROGGAN, A ;
SCHWEITZER, D ;
MULLER, G .
PHYSICS IN MEDICINE AND BIOLOGY, 1995, 40 (06) :963-978
[7]   Diffuse radiation in the galaxy [J].
Henyey, LG ;
Greenstein, JL .
ASTROPHYSICAL JOURNAL, 1941, 93 (01) :70-83
[8]  
HITZENBERGER CK, 1991, INVEST OPHTH VIS SCI, V32, P616
[9]   OPTICAL COHERENCE TOMOGRAPHY [J].
HUANG, D ;
SWANSON, EA ;
LIN, CP ;
SCHUMAN, JS ;
STINSON, WG ;
CHANG, W ;
HEE, MR ;
FLOTTE, T ;
GREGORY, K ;
PULIAFITO, CA ;
FUJIMOTO, JG .
SCIENCE, 1991, 254 (5035) :1178-1181
[10]   Dynamic coherent focus for transversal resolution enhancement of OCT [J].
Lexer, F ;
Fercher, AF ;
Sattmann, H ;
Drexler, W ;
Molebny, S .
COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICAL SCIENCE AND CLINICAL APPLICATIONS II, PROCEEDINGS OF, 1998, 3251 :85-90