Systematic synthesis of specifically 13C/2H-labeled nucleosides from [ul-13C6]-D-Glucose

被引：19

作者：

Ono, A ^{[1
]}

Shiina, T ^{[1
]}

Ono, A ^{[1
]}

Kainosho, M ^{[1
]}

机构：

[1] Tokyo Metropolitan Univ, Fac Sci, Dept Chem, Tokyo 1920397, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(98)00432-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A systematic approach, which combines previously reported reactions with appropriate modifications, was established for preparing a variety of selectively deuterated nucleosides from glucose. We have developed a systematic method of synthesizing specifically deuterated nucleosides from glucose. Selectively C-13/H-2-doubly labeled nucleosides, such as [1',2',3',4',5'-C-13(5);3',5'-H-2(2)]- and [1',2',3',4',5'-C-13(5);4',5'-H-2(2)]-adenosines, have been synthesized starting from [ul-C-13(6)]-D-glucose. These labeled nucleosides are very useful for precise conformational analyses of nucleic acids in solution by heteronuclear multidimensional NMR spectroscopy. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2793 / 2796

页数：4

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