Regional differences in blood-nerve barrier function and tight-junction protein expression within the rat dorsal root ganglion

被引：48

作者：

Hirakawa, H

Okajima, S

Nagaoka, T

Kubo, T

Takamatsu, T

Oyamada, M ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pathol & Cell Regulat, Kamigyo Ku, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Orthopaed, Kamigyo Ku, Kyoto 6028566, Japan

来源：

NEUROREPORT | 2004年 / 15卷 / 03期

关键词：

blood-nerve barrier; claudin; dorsal root ganglion; occludin; peripheral nerve; tight junctions; vascular permeability;

D O I：

10.1097/00001756-200403010-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To elucidate blood-nerve barrier function and tight-junction protein expression in the dorsal root ganglion (DRG), we analyzed the vascular permeability in the rat DRG by i.v. administration of fluorescent Evans-blue albumin (EBA) and compared it with the localization of claudin-1, claudin-5, and occludin by immunoconfocal microscopy. In the cell body-rich area within the DRG, extravascular leakage of EBA was noted and claudin-5 but neither claudin-1 nor occludin was detected. Conversely, in the nerve fiber-rich area within the DRG, no extravascular leakage of EBA was observed and both claudin-5 and occludin but no claudin-1 were detected in the blood vessel. These results demonstrate regional differences in the blood-nerve barrier function and tight-junction protein expression within the DRG.

引用

页码：405 / 408

页数：4

共 18 条

[1] Tight junctions: Closing in on the seal [J].