A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13

被引：22

作者：

Muller, AJ

Teresky, AK

Levine, AJ

机构：

[1] Rockefeller Univ, New York, NY 10021 USA

[2] Dupont Merck Pharmaceut Co, Glenolden, PA 19036 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 15期

关键词：

D O I：

10.1073/pnas.140208197

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inbred 129 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes. The inherent genetic defects that underlie male CCT susceptibility in the 129 mouse strain are unknown. CCT incidence is increased in 129 strain males that lack functional p53 protein, and we have used this finding to facilitate the generation of panels of GCT-bearing intercross and backcross mice for genetic mapping analysis. A 129 strain locus, designated pgct1, that segregates with the male CCT phenotype has been identified on chromosome 13 near D13Mit188. This region of murine chromosome 13 may be syntenic to a portion of human chromosome 5q that is implicated in male GCT susceptibility in humans.

引用

页码：8421 / 8426

页数：6

共 44 条

[1] A MUTATION IN THE TER GENE CAUSING INCREASED SUSCEPTIBILITY TO TESTICULAR TERATOMAS MAPS TO MOUSE CHROMOSOME-18 [J].