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IL-6 and APPs: anti-inflammatory and immunosuppressive mediators

被引：526
作者：
Tilg, H
Dinarello, CA
Mier, LW
机构：
[1] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV INFECT DIS,DENVER,CO 80262
[2] TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV HEMATOL ONCOL,BOSTON,MA 02111
[3] TUFTS UNIV,SCH MED,BOSTON,MA 02111
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 09期
关键词：
D O I：
10.1016/S0167-5699(97)01103-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Acute inflammation is accompanied by changes in the concentrations of acute phase proteins (APPs). While much is known about the cytokines involved in the initiation of inflammation, less is known about the mediators involved in its resolution. Recent data suggest that interleukin 6 (IL-6) and IL-6-regulated APPs are anti-inflammatory and immunosuppressive, and may negatively regulate the acute phase response.
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收藏
页码：428 / 432
页数：5
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