Punc, a novel mouse gene of the immunoglobulin superfamily, is expressed predominantly in the developing nervous system

被引：23

作者：

Salbaum, JM ^{[1
]}

机构：

[1] Neurosci Inst, San Diego, CA 92121 USA

来源：

MECHANISMS OF DEVELOPMENT | 1998年 / 71卷 / 1-2期

关键词：

axon guidance; cell adhesion molecule; cell differentiation; cell proliferation; cell surface; development; differential display; downregulation; embryo; gene expression; homeodomain; immunoglobulin superfamily; islet-1; limb bud; mesoderm; midbrain; motorneuron; mouse; neural plate; neuroepithelium; transcription factor; transgenic mice;

D O I：

10.1016/S0925-4773(98)00005-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A search for genes regulated by the LlM/homeodomain transcription factor islet-l during development identified the novel mouse gene punc (putative neuronal cell adhesion molecule). Punc is a member of the immunoglobulin superfamily. exhibits a novel configuration of four immunoglobulin domains and two fibronectin-type III repeats, and resembles proteins involved in axon guidance. Punc expression in the embryo occurs in restricted patterns in both the nervous system and limb mesoderm. A sharp decrease in punc expression after embryonic day 11.5 suggests a function for punc early in mouse embryogenesis. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：201 / 204

页数：4

共 8 条

[1]

[Anonymous], 1994, MANIPULATING MOUSE E

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