The angiogenic factors CXCL8 and VEGF in breast cancer: regulation by an array of pro-malignancy factors

被引:52
作者
Azenshtein, E
Meshel, T
Shina, S
Barak, N
Keydar, I
Ben-Baruch, A [1 ]
机构
[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Sourasky Med Ctr, Dept Oncol, IL-64239 Tel Aviv, Israel
关键词
breast cancer; CCL2; CCL5; CXCL8; EGF; hormones; VEGF;
D O I
10.1016/j.canlet.2004.05.024
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The regulation of secretion of the angiogenic factors CXCL8 and Vascular Endothelial Growth Factors (VEGF) was determined in breast tumor cells and in monocytic cells (as host cells that contribute to breast cancer). CXCL8 secretion, and partly the secretion of VEGF, were up-regulated in monocytic cells, but not in breast tumor cells, by the CC chemokines CCL5 and CCL2. EGF potently up-regulated CXCL8 secretion by breast tumor cells, and its effect was promoted by a consecutive treatment of the cells by estrogen and progesterone. These findings provide evidence for a complex set of pro-malignancy factors that may control the expression of angiogenic mediators at breast tumor sites. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:73 / 86
页数:14
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