Value of the serum alpha-L-fucosidase activity in the diagnosis of colorectal cancer

被引:47
作者
Ayude, D [1 ]
Fernández-Rodríguez, J [1 ]
Rodríguez-Berrocal, FJ [1 ]
Martínez-Zorzano, VS [1 ]
de Carlos, A [1 ]
Gil, E [1 ]
de la Cadena, MP [1 ]
机构
[1] Univ Vigo, Fac Ciencias, Dept Bioquim Genet & Inmunol, E-36200 Vigo, Spain
关键词
alpha-L-fucosidase; colorectal cancer; serum; tumor markers; diagnostic value;
D O I
10.1159/000012188
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: The purpose of this study was to assess the value of the serum levels of alpha -L-fucosidase activity in the diagnosis of patients with colorectal cancer. Methods: Using a fluorometric method we analyzed the alpha -L-fucosidase activity in preoperative sera from 137 colorectal cancer patients and in sera from 232 donors. Results: The enzymatic activity of alpha -L-fucosidase was significantly lower (p < 0.001) in patients (4.8 +/- 3.09 U/ml) than in donors (10.5 +/- 5.46 U/ml). Using the ROC curve, the ideal cut-off for the diagnostic value of <alpha>-L-fucosidase activity was determined to be 5.6 U/ml. The diagnostic efficiency for colorectal cancer of alpha -L-fucosidase activity was higher than that observed for carcinoembryonic antigen (cut-off 5.0 ng/ml), especially for tumors at an early stage, Conclusions: Our results suggest that preoperative serum alpha -L-fucosidase activity may be used as a cheap and easy complementary test, in addition to standard clinical procedures routinely used for the diagnosis of colorectal cancer. Copyright (C) 2000 S. Karger AG, Basel.
引用
收藏
页码:310 / 316
页数:7
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