Preferential localization of IgG memory B cells adjacent to contracted germinal centers

被引：99

作者：

Aiba, Yuichi ^{[1
]}

Kometani, Kohei ^{[1
]}

Hamadate, Megumi ^{[1
]}

Moriyama, Saya ^{[1
,2
]}

Sakaue-Sawano, Asako ^{[3
]}

Tomura, Michio ^{[4
]}

Luche, Herve ^{[5
]}

Fehling, Hans Joerg ^{[5
]}

Casellas, Rafael ^{[6
,7
]}

Kanagawa, Osami ^{[4
]}

Miyawaki, Atsushi ^{[3
]}

Kurosaki, Tomohiro ^{[1
,2
,8
]}

机构：

[1] RIKEN Res Ctr Allergy & Immunol, Lab Lymphocyte Differentiat, Kanagawa 2300045, Japan

[2] Osaka Univ, Grad Sch Frontier Biosci, Lab Lymphocyte Differentiat, Suita, Osaka 5650871, Japan

[3] RIKEN Brain Sci Inst, Lab Cell Funct & Dynam, Wako, Saitama 3510198, Japan

[4] RIKEN Res Ctr Allergy & Immunol, Lab Autoimmune Regulat, Kanagawa 2300045, Japan

[5] Univ Clin Ulm, Inst Immunol, D-89081 Ulm, Germany

[6] NIAMSD, NIH, Bethesda, MD 20892 USA

[7] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[8] Osaka Univ, World Premier Int Immunol Frontier Res Ctr, Lab Lymphocyte Differentiat, Suita, Osaka 5650871, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 27期

基金：

日本科学技术振兴机构;

关键词：

immunoglobulin; immunological memory; PRIMARY IMMUNE-RESPONSE; IN-VIVO; MICE; VISUALIZATION; HYPERMUTATION; EXPRESSION; ANTIBODIES; RECEPTORS; INDUCTION; SELECTION;

D O I：

10.1073/pnas.1005443107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It has long been presumed that after leaving the germinal centers (GCs), memory B cells colonize the marginal zone or join the recirculating pool. Here we demonstrate the preferential localization of nitrophenol-chicken gamma-globulin-induced CD38(+)IgG1(+) memory B cells adjacent to contracted GCs in the spleen. The memory B cells in this region proliferated after secondary immunization, a response that was abolished by depletion of CD4(+) T cells. We also found that these IgG1(+) memory B cells could present antigen on their surface, and that this activity was required for their activation. These results implicate this peri-GC region as an important site for survival and reactivation of memory B cells.

引用

页码：12192 / 12197

页数：6

共 26 条

[1] Germinal-center organization and cellular dynamics [J].

Allen, Christopher D. C. ;

Okada, Takaharu ;

Cyster, Jason G. .

IMMUNITY, 2007, 27 (02) :190-202

[2] Imaging of germinal center selection events during affinity maturation [J].

Allen, Christopher D. C. ;

Okada, Takaharu ;

Tang, H. Lucy ;

Cyster, Jason G. .

SCIENCE, 2007, 315 (5811) :528-531

[3] New markers for murine memory B cells that define mutated and unmutated subsets [J].

Anderson, Shannon M. ;

Tomayko, Mary M. ;

Ahuja, Anupama ;

Haberman, Ann M. ;

Shlomchik, Mark J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (09) :2103-2114

[4]

BAINE Y, 1982, J IMMUNOL, V128, P639

[5] HEAVY-CHAIN VARIABLE REGION CONTRIBUTION TO THE NPB FAMILY OF ANTIBODIES - SOMATIC MUTATION EVIDENT IN A GAMMA-2A VARIABLE REGION [J].

BOTHWELL, ALM ;

PASKIND, M ;

RETH, M ;

IMANISHIKARI, T ;

RAJEWSKY, K ;

BALTIMORE, D .

CELL, 1981, 24 (03) :625-637

[6] The role of complement and complement receptors in induction and regulation of immunity [J].

Carroll, MC .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :545-568

[7] Visualizing the first 50 Hr of the primary immune response to a soluble antigen [J].

Catron, DM ;

Itano, AA ;

Pape, KA ;

Mueller, DL ;

Jenkins, MK .

IMMUNITY, 2004, 21 (03) :341-347

[8] STRUCTURE OF PRIMARY ANTI-(4-HYDROXY-3-NITROPHENYL)ACETYL (NP) ANTIBODIES IN NORMAL AND IDIOTYPICALLY SUPPRESSED C57BL/6 MICE [J].

CUMANO, A ;

RAJEWSKY, K .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1985, 15 (05) :512-520

[9] Visualization of specific B and T lymphocyte interactions in the lymph node [J].

Garside, P ;

Ingulli, E ;

Merica, RR ;

Johnson, JG ;

Noelle, RJ ;

Jenkins, MK .

SCIENCE, 1998, 281 (5373) :96-99

[10] Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns [J].

Hauser, Anja E. ;

Junt, Tobias ;

Mempel, Thorsten R. ;

Sneddon, Michael W. ;

Kleinstein, Steven H. ;

Henrickson, Sarah E. ;

von Andrian, Ulrich H. ;

Shlomchik, Mark J. ;

Haberman, Ann M. .

IMMUNITY, 2007, 26 (05) :655-667

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